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These are then are further degraded to salicylic acid (in the meta-cleavage pathway) or phthalic acid (in the ortho-cleavage pathway)

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For example, dairy cows exposed to seasonal heat stress (THI: 78.6 ± 4.5) for 28 days and then challenged with an intramammary LPS infusion (10 µg in 5 ml saline) on day 30 exhibited higher milk concentrations of IL-10 and TNFα, with a tendency for increased milk haptoglobin, indicating that heat stress amplified mammary inflammatory responses to LPS (Chen et al., 2023)